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Hypersensitivity to metformin hydrochloride or to any of the excipients.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Diabetic pre-coma.
Severely reduced kidney function (GFR < 30 mL/min).
Acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock.
Intra-vascular administration of iodinated contrast agents.
Acute or chronic disease which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock.
Hepatic insufficiency, acute alcohol intoxication, alcoholism.
Lactation.
